Synthesis And Characterization Of Nateglinide Derivatives: Synthesis And Characterization Of Nateglinide Derivatives

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A series of seven nateglinide analogues were synthesized successfully using 4-isopropyl cyclohexyl carboxylic acid (trans acid) as starting material, react with thionyl chloride and formed trans-4-isopropyl cyclohexane carbonyl chloride (trans acid chloride) as an intermediate which further reacted with D-phenylalanine to yield nateglinide. The derivatives were synthesized by reacting nateglinide ...

Paperback: 96 pages
Publisher: LAP LAMBERT Academic Publishing (August 8, 2015)
Language: English
ISBN-10: 3659769207
ISBN-13: 978-3659769207
Product Dimensions: 5.9 x 0.2 x 8.7 inches
Format: PDF ePub Text TXT fb2 ebook

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loroformate, and formed an unstable mix anhydride compound, which further react with primary and secondary amines to yield the nateglinide derivatives. All these molecules were characterized spectroscopically by mass spectra, IR, 1H NMR.